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By Nathan Ahlgrim Even computer programs, like DeepDream, hallucinate. Courtesy of Wikimedia Commons . Experiencing hallucinations is one of the most sure-fire ways to be labeled with one of the most derogatory of words: “crazy.” Hearing voices that no one else can hear is a popular laugh line (look no further than  Phoebe in Friends ), but it can be a serious and distressing symptom of schizophrenia and other incapacitating disorders. Anderson Cooper demonstrated the seriousness of the issue, finding the most mundane of tasks nearly impossible as he lived a day immersed in simulated hallucinations. Psychotic symptoms are less frequently the butt of jokes with increasing visibility and sensitivity, but people with schizophrenia and others who hear voices are still victims of stigma . Of course, people with schizophrenia deserve to be treated like patients in the mental healthcare system to ease their suffering and manage their symptoms, but there is a population who are at peace w...

By Andy Clark Andy Clark is Professor of Logic and Metaphysics in the School of Philosophy, Psychology and Language Sciences, at Edinburgh University in Scotland. He is the author of several books including Surfing Uncertainty: Prediction, Action, and the Embodied Mind (Oxford University Press, 2016). Andy is currently PI on a 4-year ERC-funded project Expecting Ourselves: Prediction, Action, and the Construction of Conscious Experience . In this post, I’d like to explore an emerging neurocomputational story that has implications for how we should think about ourselves and about the relations between normal and atypical forms of human experience. Predictive Processing: From Peeps to Phrases The approach is often known as ‘predictive processing’ and, as the name suggests, it depicts brains as multi-area, multi-level engines of prediction. Such devices (for some introductions, see Hohwy (2013), Clark (2013) (2016)) are constantly trying to self-generate the sensory stream – to re-creat...

By Elaine Walker Elaine Walker is the Charles Howard Candler Professor of Psychology and Neuroscience at Emory University.   She leads a research laboratory that is funded by the National Institute of Mental Health (NIMH) to study risk factors for psychosis and other serious mental illnesses.  Her research is focused on the behavioral and neuromaturational changes that precede psychotic disorders.   She has published over 300 scientific articles and 6 books.  The diagnostic process can be complicated by many factors. Most of these factors reflect limitations in our scientific understanding of the nature and course of disorders. But in the current US healthcare climate, legislative proposals concerning insurance coverage for preexisting conditions add another layer of complexity to the diagnostic process. It is a layer of complexity that is riddled with ethical dilemmas which are especially salient in the field of mental health care. The following d...

This spring, the Neuroscience Graduate Program and the Neuroethics Program at Emory University are teaming up to present the 2017 Emory Graduate Student Neuroethics Symposium entitled, The Use of Preclinical Biomarkers for Brain Diseases: A Neuroethical Dilemma.  This year’s symposium will focus on the neuroethics of preclinical detection, including discussions of the basic and clinical research being performed and the neurotechnologies being developed for the early detection of autism, schizophrenia, and Alzheimer’s disease.  The symposium will take place on Friday, April 28th from 10am to 4:30pm at Emory University and is free and open to the public. The symposium will be comprised of three sessions:  Session 1: Autism, with a focus on the ethics of conducting preclinical research. Session 2: Schizophrenia, with a focus on the ethics of interventions and treatment. Session 3: Alzheimer’s disease, with a focus on the ethics of delivering a preclinical diagnosis give...

By Sunidhi Ramesh This post is based on the January edition of the “Neuroethics and Neuroscience in the News” series in which Dr. Elaine Walker from Emory University discussed the ethics of assessing risk and treating brain diseases before they can be diagnosed. This self-portrait is often used to depict the distorted reality that many schizophrenia patients face. (Image courtesy of Wikimedia   Commons .) “This calculator,” a 2016 headline states, “can predict your risk of developing psychotic disorders.” Psychotic disorders , including schizophrenia and bipolar disorder with psychotic features, are characterized by noticeable deficits in “normal” behavior accompanied by hallucinations, delusions, paranoia, an early onset (the average age of onset is in the late teens or early twenties), and a derailed life course. Because of its early age at onset, the DALY (disability adjusted life years) value for psychosis is significantly greater than that of other illnesses (1). It’s no su...

by Arthur T. Ryan, M.A. and Elaine F. Walker, Ph.D. Arthur Ryan is a graduate student in clinical psychology at Emory University. His research focuses on understanding the etiology and neuropathology underlying severe mental illness. Elaine Walker is a Professor of Psychology and Neuroscience in the Department of Psychology at Emory University and is the Director of the Development and Mental Health Research Program, which is supported by the National Institute of Mental Health. Her research is focused on child and adolescent development and the brain changes that are associated with adolescence. She is also a member of the AJOB Neuroscience editorial board. Arthur Ryan, M.A. Over the past several decades, there has been a significant effort to minimize bias against individuals based on ethnicity and other demographic factors through the creation of seemingly impartial and objective criteria across a host of domains. For example, when the United States Federal Sentencing Guidelines wer...