Can Human Brain Tissue Make Mice Smarter? Emory Neuroethics Journal Club Review
What makes humans smart? This was the primary question posed in the final Journal Club of the Spring 2013 semester. Led by Riley Zeller-Townson, the club discussed Han et al. (2013), a paper that discusses the enhancement of learning in mice after grafting human glial progenitor cells into their brains. Riley began by explaining the paper and the work leading up to it. Most of the roles of glial cells involve supporting and protecting neurons, such as synaptic plasticity, myelination, and maintaining the blood-brain barrier (Barres, 2003). This study focuses on one subtype of glia, called astrocytes, cells that provide nutrients to neurons (Tsacopoulos et al, 1996). Neurons (shown on left) possess both axons and dendrites and are shaped differently than glial cells ( Source ). The glial cell shown on the right is an astrocyte, which is more “star” shaped due to its many branched processes (Han et al 2013). While people generally think of neurons as being the important ...